Tips for managing sleep issues from myeloma

Written by Mary Chapman | Last updated April 28, 2026
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Sleep issues are common when living with myeloma. They can be caused by myeloma-related issues such as physical discomfort, emotional stress, and even certain treatments.

Not getting enough quality sleep can affect anyone’s well-being, but especially if you are dealing with a chronic illness like myeloma. A healthy sleep routine supports your physical and mental health, which can help you better manage myeloma symptoms.

The first step to improving your sleep is to understand why and how your sleep is being disrupted and to discuss it with your doctor.

Common causes of sleep problems in myeloma

While myeloma affects everyone differently, many people with myeloma experience sleep issues.

Cancer itself can shorten sleep duration and increase the time it takes to fall asleep. Other common causes of sleep problems when living with myeloma include:

  • Bone and neuropathy pain: Some people notice bone pain at night, when shifting positions in bed. Neuropathic pain, which can affect the hands, legs, and feet, often feels like burning or tingling.
  • Corticosteroids: These medications are known to cause sleep problems, including insomnia.
  • Pain medications: Taking opiates, in particular, can suppress deep sleep and cause frequent awakenings.
  • Fatigue: You may be less active and need to nap because of daytime fatigue, which can make it difficult to sleep well at night.
  • Anxiety and depression: Myeloma can affect you emotionally, which can cause you to have trouble falling asleep, insomnia, or frequent awakenings.
  • Anemia and kidney problems: In addition to neuropathy, anemia and renal impairment may further increase the risk of secondary sleep disorders in individuals with myeloma, including sleep-related movement disorders such as nocturnal leg kicking or jerking.

How sleep can support myeloma management

Good sleep can improve your quality of life and resilience by supporting recovery and the immune system, so your body is better equipped to fight off infections and inflammation.

Getting a good night’s sleep can also decrease fatigue from myeloma and improve your mood and how well you function during the day.

You may have enough energy to do more physical activity, including exercise, which supports your overall well-being. Better-quality sleep is also associated with reduced pain sensitivity and less anxiety and depression.

Tips for better sleep

Most adults need between seven and nine hours of sleep each night.

If you are dealing with sleep disruptions, targeted strategies rooted in sleep hygiene and lifestyle adjustments can promote deeper sleep in those with myeloma.

Myeloma sleep tips include:

  • Manage night sweats, which are common in myeloma and can disrupt sleep, by choosing sleepwear and sheets made from breathable fabrics like cotton.
  • Write in a journal before going to sleep to clear your mind of any worries or anxiety you have about the uncertainties of living with myeloma.
  • Make listening to calming music or reading part of your bedtime routine.
  • Prepare for sleep by trying relaxation techniques such as mindfulness, meditation, and breathing exercises.
  • Do physical activity regularly, if you are able to.
  • Go to bed and get up at the same time every day, even on weekends. This can strengthen your body’s circadian rhythm, making it easier to fall asleep and wake up naturally.
  • Limit naps during the day. While they can help you cope with extreme fatigue, excessive napping can disrupt your nighttime sleep.
  • Take steroids, if they are part of your treatment plan, earlier in the day, as they can interfere with sleep.
  • Avoid alcohol and caffeine, especially at night. They can disrupt your natural sleep cycles and brain chemistry.

When to talk to your doctor

Talk to your myeloma healthcare team about coming up with a sleep plan based on your situation. Speak with your hematologist-oncologist if sleep problems persist or worsen. Such issues may include:

  • trouble falling asleep
  • frequent awakenings
  • excessive daytime napping
  • jerking and kicking your legs while sleeping
  • uncomfortable sensations in the legs at night
  • mood changes linked to poor sleep

Some sleep-related questions to ask include:

  •  Could my treatment or medications be affecting my sleep?
  •  Should I be evaluated for a sleep disorder?
  •  Are there safe sleep aids or alternatives I can try?
  •  Can my fatigue be related to a sleep problem?

Joining a support group can also help you navigate the emotional challenges that can interfere with getting a good night’s rest. The Multiple Myeloma Research Foundation and International Myeloma Foundation offer support groups.

Rare Cancer News is strictly a news and information website about the disease. It does not provide medical advice, diagnosis, or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.


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